2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-171446
    TAK-075 667931-33-1 98%
    TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. TAK-075 can stimulate the transient secretion of parathyroid hormone (PTH) in rats and can effectively prevent a significant reduction in PTH secretion caused by the accumulation of active metabolites, maintaining the normal secretion pattern of PTH. TAK-075 can be used in the research of metabolic diseases and osteoporosis.
    TAK-075
  • HY-171451
    RMGPa-IN-1 958237-73-5 98%
    RMGPa-IN-1 (Compound 10C) is a rabbit muscle glycogen phosphorylase a (RMGPa) inhibitor with an IC50 value of 82.5 μM. RMGPa-IN-1 is promising for research of diabetes.
    RMGPa-IN-1
  • HY-171828
    LysoPE (20:4/0:0) 652149-09-2
    LysoPE (20:4/0:0) is a lysophosphatidylethanolamine glycerophospholipid and is an endogenous metabolite.
    LysoPE (20:4/0:0)
  • HY-172002
    3'-O-Methylguanosine-5'-O-triphosphate sodium 98923-57-0 98%
    3'-O-Methylguanosine-5'-O-triphosphate (3'-O-Methyl GTP) sodium is a methylated derivative of Guanosine 5'-triphosphate (HY-W010737). 3'-O-Methylguanosine-5'-O-triphosphate has been used as a chain termination reagent in the preparation of early RNA polymerase II elongation intermediates.
    3'-O-Methylguanosine-5'-O-triphosphate sodium
  • HY-172003
    Isoorotidine 489-36-1 98%
    Isoorotidine is a nucleoside derivative and an isomer of the pyrimidine nucleoside Orotidine (HY-113226).
    Isoorotidine
  • HY-172020
    1,3-Diheptadecanoyl glycerol 71431-35-1 98%
    1,3-Diheptadecanoyl glycerol is a diacylglycerol that contains Heptadecanoic acid (HY-W004284) at the sn-1 and sn-3 positions.
    1,3-Diheptadecanoyl glycerol
  • HY-172021
    Didocosanoin 99880-64-5
    Didocosanoin is a diacylglycerol that contains the saturated 22-carbon fatty acid Docosanoic acid (HY-W013049).
    Didocosanoin
  • HY-172022
    Dipalmitelaidin 372516-90-0 98%
    Dipalmitelaidin is a diacylglycerol that contains the monounsaturated 16-carbon fatty acid Palmitelaidic acid (HY-N2341).
    Dipalmitelaidin
  • HY-172233
    INCB-056868 2252320-89-9 98%
    INCB-056868 is the metabolite M11 of Epacadostat (HY-15689). INCB-056868 can also serve as a substrate for BCRP. INCB-056868 is promising for research of metabolic diseases.
    INCB-056868
  • HY-172249
    NBD Sphingosine-1-phosphate ammonium 799268-48-7 98%
    NBD Sphingosine-1-phosphate (ammonium) is a sphosphingolipid.
    NBD Sphingosine-1-phosphate ammonium
  • HY-172411
    GLP-1R agonist 29 3076770-93-6 98%
    GLP-1R agonist 29 (Compound 20) is the agonist for GLP-1R that induces hGLP-1R mediated cAMP stimulation with an EC50 of 0.018 nM. GLP-1R agonist 29 exhibits good pharmacokinetics characteristics with good body exposure of AUC0-∞,sc of 77688 ng·h/mL.
    GLP-1R agonist 29
  • HY-172610
    KHK-IN-7 98%
    KHK-IN-7 (compound 2) is a ketohexokinase (KHK) inhibitor. KHK-IN-7 can be used for study of metabolic disorders.
    KHK-IN-7
  • HY-172731
    8-Oxo-dATP lithium 3056945-23-1 98%
    8-Oxo-dATP lithium, as an oxidized purine nucleoside triphosphate, is hydrolyzed by MTH1 into monophosphates, thereby preventing errors caused by its misincorporation during DNA replication or transcription.
    8-Oxo-dATP lithium
  • HY-172765
    10-POHSA 98%
    10-POHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). 10-POHSA may be a bioactive lipid with roles in metabolic syndrome and inflammation.
    10-POHSA
  • HY-173215
    3-Dimethylaminopropyl deacetylforskolin 98%
    3-Dimethylaminopropyl deacetylforskolin is a dehydro derivative of adenylate cyclase activator Forskolin (HY-15371) and may cause cross-immunoreactivity with anti-Forskolin antibodies.
    3-Dimethylaminopropyl deacetylforskolin
  • HY-173512
    mTYR-IN-1 98%
    mTYR-IN-1 (compound 3e) is a reversible and competitive mTYR inhibitor with an IC50 of 4.86 μM. mTYR-IN-1 can be used in the study of skin pigmentation.
    mTYR-IN-1
  • HY-17374R
    Benfotiamine (Standard) 22457-89-2 98%
    Benfotiamine (Standard) is the analytical standard of Benfotiamine. This product is intended for research and analytical applications. Benfotiamine (S-Benzoylthiamine O-monophosphate) is a vitamin B1 derivative that exhihibits potent antioxidative and anti-inflammatory activity. Benfotiamine can be used for the research of various secondary diabetic complications. Benfotiamine also can be used in infectious diseases such as HIV and COVID-19.
    Benfotiamine (Standard)
  • HY-17397R
    Strontium Ranelate (Standard) 135459-87-9 98%
    Strontium Ranelate (Standard) is the analytical standard of Strontium Ranelate. This product is intended for research and analytical applications. Strontium Ranelate (S12911) is an antiosteoporotic agent that acts by reducing bone resorption and promoting bone formation, thereby inducing a positive bone balance. Strontium Ranelate can also activate the calcium-sensing receptor (CaSR) in non skeletal cells, resulting in the activation of inositol 1, 4, 5-triphosphate production and mitogen-activated protein kinase signaling.
    Strontium Ranelate (Standard)
  • HY-17398R
    Mitiglinide calcium (Standard) 145525-41-3 98%
    Mitiglinide (calcium) (Standard) is the analytical standard of Mitiglinide (calcium). This product is intended for research and analytical applications. Mitiglinide Calcium (KAD-1229 anhydrous), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide Calcium is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide Calcium can be used for the research of type 2 diabetes.
    Mitiglinide calcium (Standard)
  • HY-17399R
    Racecadotril (Standard) 81110-73-8 98%
    Racecadotril (Standard) is the analytical standard of Racecadotril. This product is intended for research and analytical applications. Racecadotril (Acetorphan) is a neutral endopeptidase (NEP) inhibitor. Racecadotril and its active metabolite Thiorphan inhibits purified NEP activity from mouse brain with Kis of 4500 and 6.1 nM, , respectively. Antidiarrheal agent.
    Racecadotril (Standard)
Cat. No. Product Name / Synonyms Application Reactivity